Dendritic Cell Vaccine and its Application in Cancer Therapy

Dendritic Cell Vaccine and its Application in Cancer Therapy

Dendritic cells (DCs) are the most potent antigens presenting cells in the immune system. They have a high capacity to trigger antigen-specific immune responses and promote both adaptive immunity and innate immunity. In the past decade, DC vaccine has been introduced as a new therapeutic strategy in cancer patients. DC-based immunotherapy is safe and can promote antitumor immune responses and p...

Targeted Cancer Therapy by Dendritic Cell Vaccine

Dendritic Cell Maturation is a Critical Step in Dendritic Cell Vaccine Preparation for Cancer Therapy

Background: Dendritic cell (DC) vaccine is a hopeful approach for cancer treatment. In clinical trials, DC vaccines have produced clinical responses in some cancer patients. However, DC vaccines efficacy is not satisfactory in most types of cancer and more efforts must be done to improve their effectiveness in advanced cancers. Understanding the influence of tumor cells and tumor stromal cells ...

The biological effects induced by high-charged and energy particles and its application in cancer therapy

The radiobiological effects of high atomic number and energy (HZE particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. Space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. HZE particles pose a significant cancer risk to astronauts on prolonged space missions. With ...

Cancer Therapy: Clinical Phase I Dendritic Cell p53 Peptide Vaccine for Head and Neck Cancer

Background: p53 accumulation in head and neck squamous cell carcinoma (HNSCC) cells creates a targetable tumor antigen. Adjuvant dendritic cell (DC)–based vaccination against p53was tested in a phase I